甘肃省动物尘肺的病理学研究

Pathological Studies on Pneumoconiosis in Animals

用光镜与电子探针微分析技术,对817头动物的肺和支气管淋巴结进行了研究,并在家兔成功地复制出尘肺病理模型。首次发现在甘肃省河西地区的多种动物中存在无机尘肺,这些尘肺均属铝硅酸盐尘肺。肺组织的主要病变包括慢性间质性肺炎和大量内含无机尘的巨噬细胞病灶与结节。作者认定,这些肺病变的发生同这一地区环境空气中粉尘含量高有关。

Studies on the lung and bronchial lymphonodes of 817 animals purchased from Gansu province were carried out by light microscope and electron probe microanalytic technique, and pneumoconiosis pathomodel was reproduced successfully in rabbits by inhaling the dust in 1988--l990. The pneumoconiosis was found in various species of animals in Hexi corridor of Gansu province, which was the first event in this country. The disease was an aluminum silicate pneumoconiosis. Aluminum and silicon were the predo- minant elements in the dust particles of the lungs and lymphonodes. In the pulmonary tissue, the essential lesions included chronic interstitial pneumonia with large numbers of foci and nodules of macrophages con- taining inorganic dusts. The authors firmly believe that the occurrence of the pathological changes in lung has a relation with more dust content in environmental air in the area. The pathogenesis and preventive measures of the pneumoconiosis are discussed.