期刊文献+

存活素与泌尿生殖系肿瘤

下载PDF
导出
摘要 存活素 (survivin)是凋亡抑制蛋白 (inhibitionapoptosisprotein ,IAP)家族成员 ,具有独特的蝶形邻结样二聚体结构 ,通过抑制半胱天冬蛋白酶 3和半胱天冬蛋白酶 7(caspase 3,caspase 7)活性而抑制细胞凋亡 ,参与细胞周期调控 ,在泌尿生殖系肿瘤中广泛表达。
作者 曹贵华
出处 《国外医学(临床生物化学与检验学分册)》 2003年第1期6-7,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
  • 相关文献

参考文献20

  • 1Adida C;Crotty PL;McGrath J.Developmentallyregulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation,1998(01).
  • 2Chantalat L;Skoufias DA;Kleman JP.Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual α-helicals extensions[J],2000(06).
  • 3Muchmore SW;Chen J;Jakob C.Crystal structure and mutagenic analysis of the inhibitor of apoptosis protein survivin,2000(01).
  • 4Akoufias DA;Mollinari C;Lacroix FB.Human sur vivin is a kinetochore-associated passenger protein,2000(07).
  • 5Ambrosini G;Adida C;Sirugo G.Induction of apoptosis and inhibition of cell proliferation by survivin gene tar geting[J],1998(18).
  • 6Ambrosini G;Adida C;Altieri DC.A novel anti-ap optosis gene survivin expressed in cancer and lymphoma[J],1997(03).
  • 7Shin S;Sung BJ;Cho YS.An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7[J],2001(04).
  • 8Li F;Ambrosini G;Chu E Y.Control of apoptosis and mitotic spindle checkpoint by survivin[J],1998(6711).
  • 9Zhao J;Tenev T;Martins LM.The ubiquitin-proteasome pathway regulates survivin degradation in a cell cy cle-dependent manner,2000(23).
  • 10Li F;Ackermann EJ;Bennett CF.Pleiotropic cell division defects and apoptosis induced by interference with survivin function[J],1999(08).

共引文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部