老年慢性肾功能衰竭患者血清唾液酸和脂蛋白(a)的测定

Determination of serum sialic acid and lipoprotein level in old patients with chronic renal failure

目的 研究老年慢性肾功能衰竭 (chronicrenalfailure ,CRF)患者血清中唾液酸和脂蛋白 (a)水平的变化及其临床意义。方法 采用单一试剂显色法测定唾液酸 ,用透射比浊法检测载脂蛋白 (a) ,对 4 5例健康青年组、33例健康老年组和 38例老年CRF组进行测定。结果 老年CRF患者血清唾液酸 [(76 3± 15 8.6 )mg/L]及脂蛋白 (a)[(2 19.6± 97.3)mg/L]水平均明显高于健康青年组 [(5 2 3±72 .8)mg/L、(111.3± 72 .8)mg/L]和健康老年组 [(5 86± 92 .7)mg/L]、[(14 1.4± 10 1.2 )mg/L],差异有显著意义 (P <0 .0 1)。但健康老年组与青年健康组血清唾液酸含量则无明显变化。老年CRF患者血中唾液酸和脂蛋白 (a)水平有一定的相关性 (r =0 .80 5 ,P <0 .0 5 )。结论 检测血清唾液酸和脂蛋白 (a) ,对老年CRF患者病情的判定有一定价值 ,也可为临床提供更有价值的预防判断指标 。

Objective To investigate the changes of serum siale acid and lipoprotein(a) with chronic renal failure in the aged.Methods Thirty eight cases of old patients with chronic renal failure and 45 cases of young healthy control and 33 cases of old healthy were enrolled in this study. Sialic acid was determined by mono chemical reagent exposure and lipoprotein(a) was determined by scattering turbimetury.Results Siale acild [(763± 158.6 ) mg/L]and lipoprotein(a) [( 219.6 ± 97.3 ) mg/L] level in patients with old chronic renal failure were much higher than that in normal young and old controls [(523± 72.8 ) mg/L,( 111.3 ± 72.8 ) mg/L],[(586± 92.7 ) mg/L,( 141.4 ± 101.2 ) mg/L](P< 0.001 ).SA level was no statistical difference in the healthy old and young ones. Serun siale acid and lipoprotein(a) levels in old patients of chronic rend failure have certain correlation (r= 0.805 ,P< 0.05 ).Conclusion It is suggested that serum siale acid and lipoprotein(a)level determination are valuable for old chronic renal failure diagnosis and prognosis judgement.It could also provide an important indication for old chronic renal failure treatment in clinical practice.