摘要
目的 :评估明日叶保健茶的毒性及致突变性和致畸性。方法 :采用急性毒性试验、 Ames试验、微核试验、小鼠精子畸形试验、骨髓细胞染色体畸变试验、 3 0 d喂养试验和传统致畸试验等。结果 :急性毒性试验为实际无毒级 ;致突变试验为阴性 ;在 3 0 d喂养试验中 ,未见引起大鼠的整体健康状况、生理生化功能和器官组织形态学各重要指标的异常变化 ;在传统致畸试验中未见发育毒性。结论 :“明日叶保健茶”在推荐剂量 [3 g/ (d·人 ) ]下 。
Objective:To evaluate the toxicity?mutagenicity and teratogenicity of angelica keiskei koidzumi tea.Methods:Acute toxicity test? Ames test?micronucles test?spermatozoon aberration test?bone marrow cells chromosome aberration test?30d feed test and traditional teratogenicity test were conducted.Results:The acute toxicity wasnt effect level; The frequency of mutagenicity?teratogenicity and 30d feed test in each dose group were not significantly different compared with control group,theAnglica keiskei koidzumi tea had no mutagenicity?teratogenicity and growth toxicity.Conclusions:It is safe under the dose of 3g in one day.
出处
《现代预防医学》
CAS
2003年第1期26-28,共3页
Modern Preventive Medicine
关键词
明日叶保健茶
致突变性
致畸性
Angelica keiskei koidzumi
Mutagenicity
Teratogenicity
