摘要
目的 :优选丹参降压颗粒剂的最佳提取工艺。方法 :采用L9(34)正交设计 ,以水溶性酚酸、固形物得率为筛选指标 ,考察浸泡时间、煎煮次数、煎煮时间、加水量4个因素对提取的影响。结果 :最佳提取工艺为药材粉碎过20目筛 ,混匀后用8倍水浸泡1 5h ,煎1 5h ,第2次6倍水煎1 0h。结论 :本工艺经中试试验 ,重现性好。
OBJECTIVE:To find the optimal extraction method for Danshen granules METHODS:According to the orthogonal design L9(34),four factors in extraction were optimized,i e soak duration,decocting times,decocting duration and amount of water added The content of salvianolic acid and the weight of solids were taken as indices RESULTS:The best extracting condition was that 20 mesh size of particles was soaked in eight times amount of water for 1 5h,decocted for 1 5h at first,and then six times amount of water for 1 0h CONCLUSION:This technique is highly repeatable in pilot-experiment
出处
《中国药房》
CAS
CSCD
2003年第2期77-78,共2页
China Pharmacy
关键词
水溶性酚酸
原儿茶醛
正交试验
提取工艺
salvianolic acid
protocatechualdehyde
orthogonal design
extraction method
