头孢他啶与头孢噻肟治疗新生儿败血症临床疗效比较

A clinical study on the effects of ceftazidime and cefotaxime on neonatal septicemia

目的:评价头孢他啶和头孢噻肟治疗新生儿败血症的临床效果。方法:以头孢呋辛作对照,回顾性观察头孢他啶和头孢噻肟在新生儿败血症治疗中的疗效及安全性。结果:头孢他啶组、头孢噻肟组的有效率分别为91.30％、94.12％,与对照组头孢呋辛组(89.12％)比较均无显著差异(P>0.05);不良反应发生率也无显著差异(P>0.05);但头孢噻肟钠组与头孢他啶组住院天数均比对照组短(P<0.05)。结论:头孢他啶与头孢噻肟可作为新生儿败血症治疗的首选药物。

Objective: To evaluate the clinical effects of ceftazidime and cefotaxime on neoantal septicemia. Methods: Compared with a controll group of cefuroxime, a retrospective investigation was made to study the clinical effects and safety of ceftazidime and cefotaxime in treating the neonatal septicemia. Results: The incidence of positive value for treatment in the cefazidime and cefotaxime groups were 90.91% and 94. 12%, respectively. Compared with that of control group of cefuroxime (89. 12% ), the differences were not significant. The rate of ADR of two groups with different drugs was not different significantly, either ( P > 0. 05) . But the periods of hospitalization of the patients of ceftazidime and cefotaxime groups were shorter than that of control group significantly ( P < 0. 05). Conclusion: Ceftazidime and cefotaxime are of first choice for treating neonatal septicimia.