母婴间TTV、HBV和HCV的重叠感染

Research on TTV,HBV and HCV suprainfection between Parturient and Newborn

目的 :探讨母婴间 TTV、HBV和 HCV重叠感染的分布及感染率。方法 :对 1 40例产妇及新生儿血清应用聚合酶链反应 ( PCR)、反转录聚合酶链反应 ( RT- PCR)检测 TTV、HBV和 HCV感染的阳性率。结果 :HBV- DNA及 HCV- RNA双重阳性产妇的新生儿双重阳性率为 1 0 0 % ,HBe Ag阳性产妇的新生儿 HBe Ag阳性率为 82 % ,抗 - HCV阳性产妇的新生儿阳性率为 75 % ,HBe Ag阳性并发 TTV阳性产妇的新生儿阳性率为 73% ,HCV并发 TTV阳性产妇的新生儿阳性率为 66.6%。结论 :母婴间存在 TTV并发 HCV。

Objective: to prove the existence of HBV, HCV and TTV coinfection between parturient and newborn. Moreover it can help to reduce morbidity of vertical transmission of viral hepatitis. Methods: The infection of HBV, HCV and /or TT virus were detected in serum samples of 140 parturient and newborn by means of PCR and RT PCR. Results: The positive rate of newborns whose mothers were both HBV DNA and HCV RNA positive were 100%. The positive rate of newborns whose mothers were HBeAg positive were 82%. The positive rate of newborns whose mothers were HCV Ab positive were 75%. The positive rate of newborns whose mothers were both HBeAg and TTV positive were 73%. The positive rate of newborns whose mothers were both HCV Ab and TTV positive were 66.6%. Conclusion:There exists HBV, HCV and TTV coinfection between mother and newborn. The blockage of transmission routes can do benefit to enhance population disposition and prevent vertical transmission.