摘要
目的 对抗疟药物青蒿素 ( )进行了生物转化研究。方法 利用长春花及银杏植物细胞悬浮培养细胞进行生物转化。用硅胶柱色谱进行产物的分离 ,波谱方法鉴定产物的结构。结果 此两种植物悬浮细胞体系均能将青蒿素转化成 3α-羟基去氧青蒿素 ( )。结论 此两种植物悬浮细胞体系均能有效转化青蒿素。
Object To investigate the biotransformation of the antimalarial compound artemisinin (Ⅰ) by Catharanthus roseus and Ginkgo biloba cell suspension cultures Methods Plant tissue culture technology was employed The product was isolated on silica gel column chromatography and its structure was elucidated by spectroscopic evidence Results One product was obtained and its structure was characterized as 3α hydroxydeoxyartemisinin (Ⅱ) Conclusion Both of C roseus and G biloba cell suspension cultures can bioconvert artemisinin
出处
《中草药》
CAS
CSCD
北大核心
2003年第2期166-168,共3页
Chinese Traditional and Herbal Drugs
基金
We thank the National Outstanding Youth Foundation by NSF of China
Trans-Century Training Program Foundation for the Talents by the Ministry of Education for financial support.
关键词
长春花
银杏
生物转化
青蒿素
悬浮细胞
Catharanthus roseus (L ) G Don
Ginkgo biloba L
biotransformation
artemisinin
cell suspension culture
