摘要
目的 :比较阿米卡星 (AMK)气管内与静脉给药后药动学参数的差异。方法 :对 16例肾功能正常 ,采用不同给药方法 ,使用AMK治疗的住院患者 ,用TDX法测定血药浓度 ,分析药动学参数。结果 :显示两种给药途径的药时曲线均符合二室模型 ,主要药动学参数比较无显著差异 (P >0 .0 5 ) ,气管内给药的绝对生物利用度为 94 % ,疗效确切。结论 :采用气管内给药法 ,可降低血药浓度 。
OBJECTIVE To compare pharmacokinetic parameters of amikacin after intratracheal administration with intravenous infusion. METHODS Sixteen patients with normal renal function were given amikacin with different pathways. Serum concentrations of amikacin were determined using TDx. The data were analysed with 3P87. RESULTS The drug concentration time profile confirmed to the two compartments model in all patients with two administration pathways. No significant difference in pharmacokinetics was found between two groups ( P > 0.05 ). Absolute bioavailability of amikacin with intratracheal administration was 94%. CONCLUSIONS The result indicated that the theraputic effect be the same by intratracheal administration method as by intravenous infusion method but the side effect of the drug be lower by the former method.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2003年第2期97-98,共2页
Chinese Journal of Hospital Pharmacy
关键词
阿米卡星
药动学
气管内给药
amikacin
pharmacokinetics
intracheal administration
patient
