p15蛋白在骨肉瘤中表达的研究

Expression of p15 protein in Osteosarcoma

目的:研究p15蛋白在骨肉瘤中的表达,探讨其表达与骨肉瘤的相关性。方法:采用S-P免疫组化方法,检测22例骨肉瘤中p15的表达;结果:p15蛋白在22例骨肉瘤中表达的阳性率为54.5％,而20例骨软骨瘤中阳性率为15.0％。骨肉瘤p15蛋白表达与骨软骨瘤相比差异具有统计学意义(x2=7.13,P<0.01)。结论:p15蛋白的表达与肿瘤的恶性度相关,与骨肉瘤的发生、发展具有相关性。

Objective: Our aims were to study the expression of p15 protein in osteosarcoma and to investigate the function of p15 protein in carcinogenesis and development of osteosarcoma. Methods: We detected p15 protein in 22 cases of osteosarcoma, and immunohistological method was used. Results: The positive rate of p15 protein in 22 cases of osteosarcoma in this study was 54. 5% ,and 15. 0% in 20 cases of osteochondroma. Significant difference can be seen between osteosarcoma and osteochondroma. Conclusion: The expression of p15 protein was relevant to histological type, and may be associated with carcinogenesis and development of osteosarcoma.