博乐欣合并认知行为疗法治疗惊恐障碍对照研究

Venlafaxine plus cognitive behavior therapy in treatment of panic disorder.

目的 观察博乐欣合并认知行为疗法对惊恐障碍的治疗效果。方法 将符合CCMD-2-R诊断标准的37例惊恐障碍患者分为治疗组和对照组,治疗组给予博乐欣(50—150mg/d)合并认知行为治疗,对照组只给予博乐欣(50—150mg/d)治疗,应用临床标准疗效及HAMA和CGI—SI定期评定;观察6个月。结果 在治疗1个月、3个月和6个月时,治疗组疗效均优于对照组,具有极显著性统计学意义(P<0.01)。两组仅个别病人在治疗的前2周出现头痛、恶心、胃不适症状,无需处理,尤以合并认知治疗组显著较轻。结论 博乐欣合并认知行为治疗效果优于单用药物的治疗,且可明显缩短疗程,减少医疗开支。

Objective To study the effect of venlafaxine plus cognitive behavior therapy in treatment of panic disorder. Methods 37 outpatients who met CCMD-2-R for panic disorder were assigned to therapeutic group(n = 19)and control group(n= 18)for 6 months. Therapeutic group were given venlafaxine (50-150mg/d)in addition to congnitive behavior therapy,and control group were given venlafaxine (50-150mg/ d)only. The clinical effect was assessed with HAMA , CGI-SI at the end of 1 month, 3 months and 6 months. Results The therapeutic efficacy in venlafaxine plus cogntive behavior therapy group was significantly higher than that in control group. Conclusion Venlafaxine plus cognitive behavior therapy has better effect in treatment of panic disorder.