舒必利临床效应与血药浓度的关系

A study on the relationship between clinical efficacy of sulpiride and serum concentration.

目的 探讨舒必利治疗偏执型精神分裂症的临床效应与血药浓度之间的关系。方法 采用高效液相色谱法测定舒必利血浓度;用BPRS、SANS总分与血浓度作指数和对数曲线拟合分析临床疗效的关系;将TESS总分与血药浓度作直线相关分析判断不良反应与血药浓度的关系。结果 未发现BPRS减分与血浓度相关(P>0.05);TESS加分值与血浓度直线相关(r=0.347,P<0.05)。结论 血药浓度高于或在6mg/L时不良反应增加。

Objective To investigate the relationship between clinical efficacy of sulpiride and serum concentration in paranoid schizophrenia. Methods Serum sulpiride concentration was determined with HPCL method. BPRS,SANS and TESS were used to assess clinical efficacy and side effects. Results There was no relation between the decrease of BPRS and serum concentration. The increase of TESS had significant linear correlation with serum concentration. Conclusion With the increase of serum concentration of sulpiride,the TESS had significantly increased.