氧化苦参碱治疗慢性乙肝肝纤维化的临床研究

Clinical study of the effect of oxidized bitter alkali on fibrosis induced by Chronic hepatitis B

目的 探讨氧化苦参碱对慢性乙肝肝纤维化的临床疗效。方法 经肝组织病理检查筛选 98例慢性乙肝肝纤维化病人 ,用氧化苦参碱 10 0mL静滴 ,6月后观察其HBV DNA定量 ,血清HA、LN、PCⅢ及肝组织病理变化。并设 5 4例对照组进行比较。结果 与对照组比较 ,治疗组病人HBV DNA阴转率高于对照组 ,其HA、LN、PCⅢ均较对照组明显降低 ,肝组织病理检查 ,肝纤维化程度明显减轻 ,减轻程度明显高于对照组。结论 氧化苦参碱通过其抗病毒 ,稳定肝细胞膜 ,抑制贮脂细胞增生 ,减少细胞外基质(ECM)的形成 。

Aim To study the clinical effect of oxidized bitter alkali on Hver fibrosis induced by chronic hepatitis B. Methods Ninty eight examples were chosen from chronic hepatitis B liver fibrosis patients by liver histopathology check.They were treated with 400 mg oxidized bitter alkali by muscle injection and the HBV DNA ration,changes of serum HA,LN,PCⅢ and fiberized liver histopathology were examined six months later.A control group of 54 cases was established to compare with.Results Compared with the control group,its HBV DNA negative rate was higher than that in the control group,its serum HA,LN,PCⅢ reduced obviously,and the fibrosis level decreased significointly compared with that of the control group by histopathology check.Conclusion Oxidized bitter alkali plays an effective role in resisting fiberization through its antiviral function,stabilizing the cell membrane of liver,suppressing the storing fat cell and reducing the forming of ECM.