检测血小板计数及血清纤维连接蛋白对评价肝硬化病情的意义

The significance of platelet counter and serum fibronectin for assessing the state of liver cirrhosis

目的 研究血小板计数及血清纤维连接蛋白对评价肝硬化病情的意义。方法 对 63例肝硬化病人按Child Pugh分级 ,采用免疫比浊法分别测定其血清Fn水平 ,并在日本MEK— 8118K全自动血液分析仪上对其进行血小板计数 ,与 61例健康对照比较。结果 肝硬化组PLT、Fn检测值明显低于正常对照组 (P <0 0 1) ,且随着肝硬化病情的加重 ,PLT、Fn呈渐进性下降 ,差别有显著意义。结论 血小板计数、血清Fn水平测定可作为诊断肝硬化的一种补充指标 ,对筛查肝硬化有一定价值 。

Aim To study the significance of platelet counter and serum fibronectin for assessing the state of liver cirrhosis.Methods 63 cases of liver cirrhosis were classfied by Child Pugh,immune turbidity were performed to determine the serum levels of Fn,at the same time,PLA was determined by a MEK 8118K type auto blood cell counter.Results The levels of PLT and serum Fn in liver cirrhosis group were lower than those in control and were gradually decreased with progressing conditions,and the differences were obviously significant( P <0 01).Conclusions PLT,serum Fn could be used to be as a complimental parameter of the diagnosis of liver cirrhosis,and they have the important significance for assessing the state of liver cirrhosis and selecting the liver cirrhosis.