北京4家医院临床分离的肠球菌株的耐药性分析

Antimicrobial resistance of clinical isolates of enterococcus from four hospitals in Beijing

目的 深入分析北京地区分离的肠球菌的耐药表型 ,为临床合理选药提供客观实验依据。方法 按照美国临床实验室标准化委员会 (NCCLS)推荐的方法和判断标准进行纸片扩散法药敏试验 ,并用WHONET5专用软件进行分析。结果 临床分离的肠球菌中 ,粪肠球菌和屎肠球菌分别占 80 7%和 17 1% ;居前四位分离出肠球菌的标本是尿液 (33 8% )、痰液 (2 3 5 % )、脓性分泌物 (9 8% )和血液 (4 4 % )。粪肠球菌、屎肠球菌对万古霉素、替考拉宁、呋喃妥因、氯霉素、氨苄西林 ;高浓度庆大霉素的耐药率分别是 2 0 %、 1 5 % ;1 4 %、2 6 % ;11 7%、 15 5 % ;4 4 3%、 2 3 5 % ;17 7%、 6 4 2 % ;4 7 4 %、 6 4 9%。结论 泌尿系统肠球菌感染最常见。粪肠球菌和屎肠球菌对万古霉素、替考拉宁的耐药率低 ,治疗重症感染者可优先选药 ;对呋喃妥因有较好的敏感性 ;

Objective The aim of the present study was to analyze the antimicrobial resistance of enterococcal isolates from four hospitals in Beijing in order to guide the selection and use of antimicrobial agents Methods enterococcus resistance testing was performed by the disk diffusion method recommended by NCCLS Laboratory data was analyzed by WHONET5 statistic software Results The isolates of E faecalis and E faecium were 80 7% ?17 1% of all enterococcus isolates, respectively The enterococcal isolates from urine?sputum?secretion with pus and blood were 33 8%?23 5%?9 8% and 4 4% of the total isolates,respectively The resistance rate of E faecalis and E faecium to Vancomycin?Teicoplanin?Nitrofurantoin?chloramphenicol ?Ampicillin?high -level gentamicin were 2 0%?1 5%;1 4%?2 6%;11 7%?15 5%;44 3%?23 5%;17 7%?64 2%;47 4%?64 9%, respectively Conclusion Urinary infections caused by enterococcus are most frequent E faecaliis and E facium have low resistance to Vancomycin and Teicoplanin,the two drugs should be selected prior to other agents to treat severe infections They have high susceptibility rate to nitrofurantoin and high resistance rate to high- level gentamicin and streptomycin