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杀菌/渗透增强蛋白的分子结构和主要生物学功能

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摘要 杀菌 /渗透增强蛋白 (BPI)分子呈“飞镖”状结构 ,其N端和C端功能区中具有两个非极性磷脂结合口袋。目前认为 ,BPI与细菌脂多糖 (LPS)之间的结合主要与以下因素有关 :①疏水基团的作用 :即LPS疏水性乙酰基链与BPIN端口袋中非极性侧链间的相互作用 ;②静电作用 :BPIN端功能区氨基酸携带的正电荷与LPS类脂A携带的负电荷之间的相互作用。BPI主要生物学功能如下 :①对革兰阴性菌 (GNB)的抑制和杀伤作用 ;②对游离LPS的结合 /中和作用 ;③促进补体活化。
作者 丛敏
机构地区 首都医科大学
出处 《临床和实验医学杂志》 2002年第4期270-273,共4页 Journal of Clinical and Experimental Medicine
关键词 杀菌/渗透增强蛋白 革兰阴性菌 细菌脂多糖 分子结构 生物学功能
分类号 R392.11 [医药卫生—免疫学]
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参考文献10

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  • 5Ooi CE,Weiss J,Doerfler ME,et al.Endotoxin-neutralizing properpies of the 25 KD N - terminal fragment and a newly isolated 30 KD C - terminal fragment of the 55 - 60 KD bactericidal/permeability - increasing protein of human neutrophils[].The Journal of Experimental Medicine.1991
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临床和实验医学杂志
2002年 第4期

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