摘要
目的 探讨瘦素水平与妊娠期糖尿病 (GDM)发病关系以及对其胎儿生长发育的影响。方法 采用放射免疫法测定GDM孕妇 2 0例 ,糖耐量减低 (IGT)孕妇 2 2例 ,正常孕妇 2 5例血清及其新生儿脐血的瘦素水平 ,同时测定这三组孕妇的胰岛素、C肽水平 ,并测量孕前体重指数和孕期体重增加指数 ,分析其与瘦素之间的关系。结果 GDM孕妇血清瘦素、胰岛素和C肽水平明显高于IGT组及正常组 (P <0 .0 0 1)。脐血瘦素水平与胎儿体重呈正相关 (P <0 .0 5 ) 。孕妇血清瘦素水平与胎儿体重无相关。孕妇血清瘦素水平与脐血瘦素水平无相关。GDM孕妇血清瘦素与孕前体重指数明显相关 (P <0 .0 5 ) ,与孕期体重增加指数无相关。结论 (1)GDM孕妇血清瘦素水平明显高于正常孕妇 ,故瘦素可作为监控GDM的指标之一。(2 )GDM孕妇瘦素水平与脐血瘦素水平虽然不相关 ,提示胎儿瘦素是自身产生 ,但母亲糖尿病也可以影响胎儿产生更多的瘦素。
Objective: Investigate the relationship between leptin level and gestational diabetes mellitus (GDM) and its effect on foetus growth. Method: Leptin level in serum and umbilical blood of 20 GDM, 22 gestational impaired glucose tolerance (IGT) and 25 normal pregnant women were detected by radioimmunoassay (RIA) method, and with detecting insulin and C peptid level, pre?pregnant body mass index (BMI), increased gestational body mass index and newborn birth weight.Results were analyzed by the correlation analysis. Result: Serum leptin level, insulin and C peptid were significantly higher in GDM group than in IGT and normal pregnant women group(P<0.001). Umbilical blood leptin, insulin and C peptid levels were higher in GDM group than in IGT and normal pregnant group, There was significant correlation between serum leptin and pre?pregnant BMI in GDM group(P<0.05), But there was significant correlation between umbilical blood leptin level and newborn birth weigh (r=0.5727,P<0.05). However there was no correlation between serum leptin level and umbilical blood leptin level in 3 groups. Conclusion: serum leptin level was significantly higher in GDM women than in normal pregnant women. Thus we think serum leptin level can be used as an index for controle in GDM women. There is no correlation between leptin level in GDM women and umbilical blood leptin level. This shows that fetus leptin is result of auto production process. However, gestational diabetes mellitus can influence higher production of leptin in fetus.
出处
《中国优生与遗传杂志》
2003年第1期81-82,共2页
Chinese Journal of Birth Health & Heredity
