孕、产妇血清和胎儿脐带血血清骨钙素水平的动态变化

Dynamic variation of osteocalcin levels in maternal peripheral blood and fetal cord blood.

目的 为阐明孕妇和胎儿骨钙素 (osteoblastic)代谢规律 ,对各孕周期妇女外周血和胎儿脐带血骨钙素水平的动态变化进行研究。方法 采用荧光酶联免疫法对 14 2例孕妇、2 2例产妇及 34例不同孕龄胎儿的脐带血骨钙素水平进行检测。结果孕妇血清骨钙素随妊娠发展逐渐下降 ,至孕中期最低 (3.3± 1.4 6 ) μg/L ,随后又逐渐升高。分娩即刻产妇血清骨钙素 (12 .81± 4 .2 8) μg/L显著高于妊娠各阶段的水平 (P <0 .0 1) ,产后数日即显著下降至接近妊娠前的基线水平。脐带血骨钙素水平在孕中期最低 (0 .88± 0 .39) μg/L ,随后则升高 ,并且自孕 2 4w起保持于接近母体血清骨钙素水平。结论这段妊娠期是胎儿骨钙积累活跃的阶段 ,这种恒定的骨钙素水平对胎儿骨骼系统的正常发育 。

Objective: To clarify maternal and fetal osteocalcin metabolism by,investigating dynamic variation of osteocalcin levels cord blood. Methods: By routine methods, we measured serum concentrations of osteocalcin in 142 pregnant women, 21 nonpregnant women and 22 postpartum women, as well as cord blood levels of osteocalcin in 34 infants of various gestational ages. Results: Maternal osteocalcin level declined toward mid pregnancy(3.3±1.46μg/l)and increased thereafter. In addition, serum level of osteocalcin at delivery((12.81±4.28μg/l) was significantly higher than those throughout pregnancy (P<0.01).But it dramatically decreased to around the baseline level of nonpregnancy in several days postpartum. Cord blood level of osteocalcin was the lowest during mid pregnancy(0.88±0.39μg/l) and increased thereafter. It remained similar to maternal osteocalcin level from 24 weeks through 36 weeks of gestational age (P<0.01). Conclusions: This may be important to the development of fetal skeletal system, because calcium accumulation by the fetus is activating during this gestational period.