大肠癌组织Fas抗原和p53蛋白的表达及临床意义

The Expression and Clinical Significance of Fas Antigen and p53 Protein in Coolorectal Cancer

目的 探讨大肠癌组织Fas抗原及 p5 3蛋白的表达及临床意义。 方法 采用免疫组织化学方法对 32例大肠癌组织的Fas抗原 ,16例正常大肠组织及 p5 3蛋白表达进行检测和比较。 结果 Fas抗原在正常大肠组织中表达阳性 ,p5 3蛋白在正常大肠组织中表达阴性 ,Fas抗原在大肠癌组织中表达阳性率为 4 0 .6 2 %(13/ 32 ) ,p5 3蛋白在大肠癌组织中的表达阳性率为 5 3.13%。Fas抗原及 p5 3蛋白在大肠癌组织中的表达与患者性别、年龄、肿瘤大小、部位、大体分型、浸润深度、Ducks及局部淋巴结转移等无明显关系 (P >0 .0 5 ) ,Fas抗原在大肠癌组织明显下降 ,Fas抗原表达与大肠癌组织学类型及肝转移相关 (P <0 .0 5 )。p5 3蛋白表达与大肠癌肝转移相关 (P <0 .0 5 )。结论 Fas抗原在大肠癌组织中表达明显下降。随着肿瘤恶性程度的提高 ,Fas抗原表达减少。在肝转移患者中未见表达。p5 3蛋白在大肠癌组织中表达阳性 ,尤以发生肝转移者为著。Fas抗原表达下降或缺乏及 p5

Objective To investigate the clinical significance of Fas antigen and p53 protein expression in patients with colorectal cnecer.Methods Using immunohistochemistry staining,We ohserved Fas antigen and p53 protein expression in 32 cases of colorectal cancer tissue and 16 cases of normal colorectal tissue.Results Fas antigen were positive in 13(40,62%) cases of colorectal cancer.p53 protein was positive in 17(53.13%) cases of colorectal cancer tissue.The expression of Fas antigen and p53protein had no obvius relation to the patients'sex,age,area and depth of invasion,Ducks classfication,size of tumors lymphonodus metastases etc ( P>0.05).Fas antigen was remarkably down regulated in colorectal caincer.The expression of Fas antigen had relation to the type of histopathology and liver metastases ( P<0.05)The over expression of p53 protein was closely associatea with the liver metastases( P<0.05).Conclusion The Fas antigen was remarkably down regulated in colorectal cncer.especiay in patiens with liver metastases.The p53 protein was positive in colorectal cancer especially in patients with liver metastases.The abnormal expression of Fas antigen and p53 protein were associated with poor prognosis.