钙离子拮抗剂治疗早产的随机对照研究

The effect of calcium entry blocker on the management of preterm labor-a randomized controlled study.

目的 探讨钙离子拮抗剂在早产治疗中的作用。方法 采用前瞻性的研究方法 ,对心痛定治疗组 (3 1例 )及安宝对照组 (3 0例 ) ,进行疗效观察。结果 心痛定组及安宝组治疗后显效时间分别为 (3 9 14± 18 76)min及 (3 6 5 0± 17 5 3 )min ;保胎成功率分别为 70 97% (2 2 / 3 1例 )及 76 67% (2 3 / 3 0例 ) ,两组相比均无明显差异 (P>0 0 5 ) ;新生儿分娩时孕周、体重、Apgar评分均无明显差异 (P >0 0 5 ) ;心痛定组在给药 90min后心率明显增加 ,安宝组在给药后心率立即明显增加 ,与心痛定相比有极显著差异 (P <0 0 0 1)。两组不良反应分别为 8例(2 5 8% )和 2 6例 (86 7% ) ,有显著差异 (P <0 0 5 )。结论 心痛定治疗早产与安宝作用相同 ,且不良反应轻微 ,对新生儿无不良影响 。

Objective To investigate the effects of calcium entry blocker on the management of preterm labor.Methods A prospective study was performed.The therapy effect and side effect were observed between the control group using ritodrine intravenously (n=30) and the study group using nifedipine orally(n=31).Results There were no significant differences between the two groups in the tocolytic effect,which was (36\^50±17\^53)min and (39\^14±18\^76)min respectively,and in success rate,which was 76\^67%(23/30) and 70\^97%(22/31) respectively(P>0 05).There were no significant differences in neonatal outcome,e.g.gestational age,birthweight and Apgar score at 1,5,10minutes(P>0 05).The increase of maternal pulse associated with ritodrine was significantly higher than that of nifedipine group during treatment course(P<0 001).Other side effects of oral nifedipine were less than ritodrine,which was 25\^8% and 86\^7% respectively(P<0\^05).Conclusion Nifedipine is safe and effective in the management of preterm labor.So it's a good tocolytic agent.