妊高征患者凝血 纤溶及血流变学改变及意义

Changes and significances of coagulation,fibrinolysis and blood viscosity in the pregnancy induced hypertension.

目的 探讨凝血、纤溶及血流变学在妊高征发病中的作用。方法 对 69例轻、中、重度妊高征患者 ,采用美国ACL 2 0 0全血自动凝血分析仪检测凝血指标 ,用发色底物法检测组织型纤维蛋白溶酶原激活剂 (t PA)及纤溶酶原激活物抑制剂 (PAI 1) ,用LBY N5A旋转式血液流变仪测血粘度。结果 妊高征患者的部分激活的凝血活酶时间 (APTT)、凝血酶原时间 (PT)缩短 ,FG含量升高 ,PAI 1活性升高 ,血粘度升高 ,与正常非妊娠妇女、妊娠妇女相比 ,P <0 0 5 ;中、重度妊高征患者的上述指标与轻度妊高征患者相比 ,P <0 0 5 ;正常妊娠妇女与正常妇女相比 ,P >0 0 5 ,t PA在四者之间无显著性差异。结论 凝血、纤溶及血流变学改变在妊高征的发生。

Objective To explore the effects of coagulations,fibrinolysis and blood viscosity on the mechanism of pregnancy induced hypertension(PIH).Methods 69 PIH patients in different degrees were examined.Coagulation indexes were tested using ACL 200 automated coagulation instrument(made in America).Activities of t PA and PAI 1 were measured by absorbance analytical cycles.Blood viscosity was tested by LBY N5A blood viscosity instrument.Results APTT and PT were shorter,while plasma FG,activities of PAI 1 were higher as well as blood viscosity in PIH than those of normal women and normal pregnant women(P<0\^05).All these indexes in moderate and severe PIH showed significance compared with those in mild one(P<0\^05).There was no difference between normal and normal pregnant women(P>0\^05).Activities of t PA showed no difference among all the groups.Conclusion Changes of coagulations,fibrinolysis and blood viscosity play a role in the incidence and development of PIH.