尿β-HCG结合平均动脉压预测妊高征

Study on prediction of pregnancy-induced hypertension by measuring β-HCG concentration and mean arterial blood pressure.

目的 测定孕中期尿 β HCG水平结合平均动脉压 (mABP)预测妊高征的发生 ,寻求一种简便、易行并具有临床实用价值的预测方法。方法 采用放射免疫方法测定尿、血 β HCG值 ,同时测量平均动脉压进行前瞻性研究。结果 发现妊高征孕妇 16～ 2 0周尿 β HCG值 [(43 3 5 8± 40 78) μg/L]明显高于未发生妊高征者[(2 18 46± 2 4 5 8) μg/L],统计学上有显著差异 (P <0 0 5 ) ;尿 β HCG值 >43 3 5 8μg/L时 ,妊高征发生率明显增加 ;以尿 β HCG值 >43 3 5 8μg/L ,血 β HCG >43 81μg/L ,mABP≥ 12kPa为临界值 ,其阳性预测值和灵敏度分别为 42 9%和 60 0 %。结论 孕中期尿 β HCG水平结合平均动脉压可预测妊高征的发生 。

Objective To investigate the predicting value of PIH by measuring the level of β human chorionic gonadotropin(β HCG)in urine and mABP.Methods We used radioimmunoassay to measure β HCG of urine and blood,meanwhile mean arterial blood pressure from the same patients were recorded at the 16th～18th gestational week.Results Urine β HCG levels were significantly higher in pregnancies who later developed PIH than those in normal pregancies(P<0\^05).Using urine β HCG level>433 58μg/L as threshold of prediction,the positive predictive value and sensitivity were 21 4% and 60%,respectively.The positive predictive value and sensitivity of combined index(urine β HCG level>433 58μg/L combined with serum β HCG level >43 81μg/L,mABP>12kPa)were 42 9% and 60 0%,respectively.Conclusion The findings suggest that the second trimester urine β HCG can predict PIH,but its predictive value is lower than value of combined index.