毛细管胶束电动色谱在扁桃酸合成中的应用

The Application of Micellar Electrokinetic Capillary Chromatography to Analysis in the Synthesis of Mandelic Acid

扁桃酸是药物中间体,可以苯甲醛为原料在相转移催化剂作用下合成制得.为了选择最佳合成条件,提高扁桃酸的转化率,需要对合成过程中各组分的含量进行快速测定,及时指导最优合成条件的选择.产品扁桃酸中可能含有未反应的苯甲醛和副产品苯甲酸、苯甲醇等杂质.以往采用非水溶剂酸碱滴定分析法测定产品中扁桃酸的含量,但当产品中有苯甲酸等酸性物质存在时,会使测定结果偏高.由于待测样品中组分扁桃酸、苯甲酸酸性使沸点较高,

The fast and simultaneous analysis of benzyl alcohol, benzaldehyde, benzoic acid and mandelic acid was studied by Micellar Electrokinetic Capillary Chromatography (MECC). The raw material, semifinished products and purified products in the synthesis of mandelic acid were analyzed. The samples synthesized under different conditions were analyzed by using internal standard method. The resutls were used to optimize the synthesis of mandelic acid.