含铜(Ⅱ)、铁(Ⅲ)、锰(Ⅱ)双核模型化合物的超氧化物歧化酶活性

The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)

用邻苯三酚自氧化法测定自合成的N,N,N,N’,N’-四(2’-苯并咪唑甲基)-1,4-二乙氨基乙二醚(EGTB)的双核铜(Ⅱ)、铁(Ⅲ)、锰(Ⅱ)配合物的超氧化物歧化酶活性,它们均在10^(-6)～10^(-7)mol/L的浓度范围内具有50％以上的抑制率。

We synthesized and characterized a ligand, N,N,N' ,N'-tetrakis (2'-benzimidazolyl methyl)-1,4-diethylene amino glycol ether (EGTB) and its binuclear complexes containing cop-per(Ⅱ), iron(Ⅲ) and manganese(Ⅱ). An assay of superoxide dismutase (SOD) activity was performed by means of pyrogallol autoxidation. It was found that all model compounds possess excellent SOD activity and they show more than 50 % inhibition ratio in the concentration range of 10-6-10-7 mol/L of the complexes.