沙打旺中两种新三萜化合物

Studies on Two New Triterpenoids from Astragalus Adsurgens Pall

沙打旺(Astragalus Adsurgens Pall)是豆科黄芪属植物,我们对其化学成分和毒性成分进行了研究,从中分出2个新的四环三萜类化合物9和10.本文报道它们的分离鉴定工作。 1 新化合物的特征 化合物9:白色粉末,m.p.249～251℃,[a]_D^(20):—47.06°(C 0.34,CHCl_3),HRMS(M^+)m/z:486.3345,结合元素分析,分子式定为C_(30)H_(46)O_5.IR(cm^(-1))示有3367～3567(—OH),1724,1740(C—O,五元环);~1H NMR(δppm,CDCl_3,TMS),1.07～1.37处有7个—CH_3,0.44(1H,d,J=4.49 Hz),0.65(1H,d,J=4.48 Hz)AB型偶合系统和IR 3050cm^(-1)。

Two new triterpenoids have been obtained from Astragalus adsurgens pall.Their structures were elucidated by means of spectroscopic methods as (20R,24S)-3,16-dicar-bonyl-6α,25-dihydroxy-20,24-epoxy-9,19-cycloadsurgenin and (20R,245)-3,16-dicarbonyl-6α,25-dihydroxy-20,24-epoxy-23-nitrogen-9,19-cycloadsurgenin.