S-[N-取代氨基甲酰甲基]-O,O-二烷基二硫代磷酸酯类化合物的合成及其对植物的抑制活性

Synthesis and Herbicidal Activity of S-(N-Substituted Carbamino methylene)-O,O-Dialkyl Phosphorodithioate

用O,O-二烷基二硫代磷酸酯与α-卤代乙酰胺在丙酮或氯仿/水体系中反应,合成了40余种标题化合物,确定其结构;研究了酰胺分子中不同取代基对反应的影响.测定它们对植物的抑制活性发现,引入磷酰基可保持原来卤代酰胺的生物活性,但选择性却有明显提高,初步讨论了这类化合物结构与活性的规律。

In acetone or chloroform/water,a series of S-(N-substituted carbaminomethylene)-O,O-dialkyl phosphorodithioates were prepared by the reaction of ammonium O,O-dialkyl phos-phorodithioate with α-haloalkanoamide,the substituent effect of which was studied.All of the compounds were confirmed by elemental analysis,IR,1H NMR and MS.The results from the preliminary herbicidal tests show that introducing dithiophosphoryl group the herbicidal potency of the compounds were not only the same as that of a-chloroacetamide,but also their selectivity increased for the broadleaved plants.The relationship between chemical structure and activity was discussed.