对-(二乙氨基)苯基锗倍半氧化物的合成及对体外培养癌细胞的作用

Sythnesis and Effect of p-(Diethylamino)phenylgermanium Sesquioxide on Human Breastcarcinoma Cells in Vitro

<正> β-羧乙基锗倍半氧化物(Ge-132)的无毒广谱抗癌作用以及潜在的治疗艾滋病的功能~[1～3]促进了Ge-132及其衍生物合成及生物活性研究~[4～6],而对锗原子直接与苯环及其衍生物连接的有机锗倍半氧化物的研究则相对较少.我们曾报道了~[7]p-(二甲氨基)苯基锗倍半氧化物的合成、结构及对癌细胞的作用,p-(二乙氨基)苯基锗倍半氧化物的研究尚未见报道.本文采用改进的方法合成了p-(二乙氨基)苯基锗倍半氧化物(Ge-164).通过元素分析、IP、XPS和TG-DTA确定了组成和结构,观察了它对体外培养人乳腺癌细胞有丝分裂的影响.

The organogermanium compound p-(diethylamino)phenylgermanium sesquioxide was prepared with a simplified method,and the structure and properties were characterized.The results of the cancer cell culture show that in the concentration range of 1,00~0.01mmol/L of the compound in the culture solution does not nearly inhibit the mitoses of human breastcarcinoma cells.