摘要
目的 研究Ⅳ型胶原在膀胱癌中的表达及其临床意义。方法 应用免疫组化方法检测Ⅳ型胶原在65例膀胱癌及19例非肿瘤性膀胱组织中的表达,分析其与膀胱癌的病理分级、分期、复发、多发的关系。结果 Ⅳ型胶原表达与膀胱癌的病理分级、分期相关(P<0.01),而与肿瘤的复发、多发无明显相关(P>0.05),非肿瘤性膀胱组织未见Ⅳ型胶原染色。结论 Ⅳ型胶原的表达与膀胱癌浸润和转移相关,对膀胱癌的预后判断及治疗具有一定的意义。
AIM To study the expression of collagen IV in bladder cancer tissue and its clinical significance. METHODS The expression of collagen IV was dtelected by immunohistochemistry in 65 cases of bladder cancer and 19 non- tumor bladder tissues. RESULTS In bladder cancer, the expression of type collagen IV correlated with pathological grade and stage ( P < 0. 01), while it wasn' t rrelated to multi - occurrence and recurrence ( P > 0.05). CONCLUSION The expression of collagen IV is related to invasion and metastasis of bladder cancer, and it play a important role in improving treatment and prognosis of bladder cancer.
出处
《现代泌尿外科杂志》
CAS
2003年第1期15-16,共2页
Journal of Modern Urology
关键词
膀胱肿瘤
基底膜
Ⅳ型胶原
免疫组化
bladder tumor
basement membrane
collagen IV
immunohistochemistry
