核因子kappa B的结构与功能研究进展

Research progress in structure and function of NF-kappa B

核因子kappaB是一种重要的核内转录因子 ,在细胞炎性反应、免疫反应以及细胞凋亡等过程中起着举足轻重的作用。自 10多年前被发现开始 ,其结构、功能及作用机制就一直是研究的热点。作者就近年来在核因子kappaB结构和功能上的研究进展作一回顾 。

Nuclear factor kappa B is an important transcription factor. It plays a pivotal role in inflammatory responses, immune and cell apoptosis. Since its identification over ten years ago, the structure, function and mechanism of NF kappa B have always been the focus. This review presents the recent research progression of NF κB structure and function, furthermore, inhibitor and cotranscription factors of NF κB together with the interaction between NF κB and other transcription factors are also introduced hereinafter.