摘要
低温停循环 (HCA)存在时间限制问题 ,超过 4 5～ 6 0min的停循环会使术后神经系统并发症增高 ,最易受影响的是脑的高级智力功能。这是由神经元死亡导致的。神经元死亡有坏死和程序性死亡 (凋亡 )两种形式 ,这两种形式在HCA中均有发生。HCA后坏死和凋亡有时间依赖现象 ,并且各自在脑内的分布也有区别。兴奋毒性可能是不同神经元死亡的共同通路 ,神经细胞内钙超载可看作是细胞死亡的共同通路。兴奋性氨基酸通过其受体使细胞内Ca2 + 积聚 ,继而NO合成增加 ,因而引起神经元凋亡。
One problem of HCA is the limitation of time.HCA exceeding 45 to 60 minutes has higher complications of nerval system,especially the function of intelligence.This was due to neuron death.Neuron death has two forms:necrosis and apoptosis,which were both happened in HCA.The phenomenon of necrosis after HCA was different according to time and part of brain,so did apoptosis.Excitotoxicity was perhaps the common pathway of different neuron death and calcium overload was perhaps the common pathway of cell death.Excitatory amino acid induced calcium accumulation of cell through it’s acceptor.As a result,No was synthesized more.Finally,neuron apoptosis and necrosis happened.
出处
《医学研究生学报》
CAS
2003年第1期64-64,共1页
Journal of Medical Postgraduates
关键词
低温停循环
神经元
兴奋性氨基酸
钙离子
一氧化氮
兴奋毒性
Deep hypothermic circulatory arrest
Neurons
Excitatory amino acid
Calcium
Nitric oxide
Apoptosis
