比较局麻与全麻对病人血清NOS及NO浓度的影响

A comparison of the effects of local anesthesia with general anesthesia on serum levels of nitric oxide synthase and nitric oxide

目的 比较局麻与全身麻醉对手术病人血清一氧化氮合酶 (NOS)和一氧化氮 (NO)的影响。方法 根据不同麻醉方法将 2 0例颌面外科手术病人分为局麻组 (A组 )和静吸复合全麻组 (B组 ) ,每组 10例 ,在麻醉诱导前、手术切皮和手术开始后 1h抽取静脉血 3ml,分别测定血清NOS和NO浓度。结果 A组血清NOS及NO含量在切皮和术中 1h与术前比较显著增高 (P <0 0 5 ) ,B组血清NOS及NO含量在切皮和术中 1h与术前比较无显著增高 (P >0 0 5 ) ;在切皮和术中 1hB组NOS及NO含量比A组显著降低 (P <0 0 5 )。结论 静吸复合麻醉能明显抑制NOS的活性 。

Objective To compare the effects of local anesthesia with general anesthesia on serum levels of nitric oxide synthase(NOS)and nitric oxide(NO) in surgical patients.Methods 20 patients undergoing maxilloficial surgery were divided into 2 groups with 10 cases each:local anesthesia was used in group A and general anesthesia in group B.3ml blood samples were taken before induction,at skin incision and 1h during surgery for detemination of the levels of NOS and NO.Results The serum level of NOS and NO increased significantly at skin incision and 1h during surgery compared with that before induction in group A( P< 0 05),but not in group B( P> 0 05).The level of NOS and NO at skin incision and 1h during surgery were significantly lower in group B than that in group A( P< 0 05).Conclusion General anesthesia can significantly inhibit the activity of NOS and decrease the production of NO.