血脂水平在长时期内的生物学变异

Long-term biological variability of serum lipids in Chinese

目的 探讨我国人血脂水平的长期个体内生物学变异情况。方法 在多年从事血脂标准化研究及参加国际血脂标准化计划基础上长期测定一相对稳定人群的血脂水平 ,分析其中 2 3例1年多次及 10 0例 10～ 15年间每年 1次血脂测定结果。结果 两组病例血脂水平的个体内总变异(包括生物学变异和分析变异 )大致为 ,总胆固醇 10 % ,甘油三酯 2 8% ,低密度脂蛋白胆固醇 18% ,高密度脂蛋白胆固醇 16 %。结论 血脂指标 ,尤其是甘油三酯有较大生物学变异 ,临床上判断血脂水平高低时需考虑到生物学变异的存在 ,并采取适当措施减小生物学变异。

Objective To investigate long-term biological variability of serum lipids in Chinese. Methods Serum lipids in a Chinese population with relatively stable life styles were monitored with standardized measurements for 1 year (specimens were taken bimonthly) (23 subjects) or 10～15 years (yearly) (100 subjects). Results The total intra-individual variability (analytical and biological variations combined) of total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol averaged 10%, 28%, 16% and 18%, respectively. Conclusion Biological intra-individual variability is a major source of inaccuracy of cardiovascular risk assessments based on lipid measurements. Measures need to be taken to minimize biological variation when medical decisions are to be made in the treatment of lipid disorders.