期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

骨质疏松状态下骨诱导生长因子的改变 被引量：1

下载PDF
导出
摘要 骨质疏松(Osteoporosis),特别是绝经后骨质疏松和老年性骨质疏松,是一种十分常见的疾病,易发生髋部和脊柱等部位的骨折,造成严重不良后果.动物实验表明,骨质疏松妨碍骨折愈合[1,2],原因颇多,尚未完全阐明.现代骨折愈合的观念是骨诱导和骨传导,骨诱导在骨折愈合过程中发挥了非常重要的作用.骨诱导离不开骨诱导生长因子的中介,这些因子包括:转化生长因子-β(TGF-β)、骨形态发生蛋白(BMPs)、成纤维细胞生长因子(FGFs)、胰岛素样生长因子(IGFs),以及血小板衍生生长因子(PDGFs)[3].现就骨诱导生长因子的功能以及骨质疏松状态下这些生长因子的化进行综述.
作者 田敏 孙磊 陈晓亮 胡有谷
机构地区 解放军第 青岛大学医学院附属医院骨科研究所
出处 《中国骨肿瘤骨病》 2003年第1期60-62,共3页 Chinse Journal Of Bone Tumor And Bone Disease
关键词 骨质疏松 骨诱导生长因子 综述 转化生长因子-Β TGF-Β
分类号 R58 [医药卫生—内分泌]
  • 相关文献

参考文献19

  • 1[1]Kubo T, Shiga T, Hashimoto J, et al. Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet. J Steroid Biochem Mol Biol, 1999,68:197.
  • 2[2]Namkung- Matthai H, Appleyard R, Jansen J, et al. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model.Bone, 2001,28:80.
  • 3[3]Bostrom MPG, Saleh KJ. Einhorn TA. Osteoinductive growth factors in preclinical fracture and long bone defects models. Orthop Clin North AM,1999,30:647.
  • 4[4]Schmitt JM, Hwang K, Winn SR, et al. Bone morphogenetic proteins:an update on basic biology and clinical relevance. J Orthop Res, 1999, 17:269.
  • 5张勇,马平,刘健,陈苏民,蒲勤.去势大鼠骨中BMP-2,BMP-7基因表达[J].第四军医大学学报,2000,21(1):125-126. 被引量：28
  • 6[6]Centrella M, Horowitz MC, Wozney JM, et al. Transforming growth factor- beta gene family members and bone. Endocr Rev, 1994,15:27.
  • 7[7]Linkhart TA, Mohan S, Baylink DJ. Growth fractors for bone growth and repair: IGF,TGF - β and BMP.Bone, 1996,19: 1S.
  • 8[8]Marie P. Growth factors and bone formation in osteoporosis:roles for IGF- I and TGF- beta. Rev Rhum Engl Ed, 1997,64:44.
  • 9[9]Nicolas V, Prewett A, Bettica P, et al. Age - related decrease in insulin -like growth factor - I and transforming growth factor - beta in femoral cortical bone from both men and women:implications for bone loss with aging. J Clin Endocrinol Metab, 1994,79:1011.
  • 10[10]Neidlinger WC, Stalla I, Claes I, et al. Human osteoblasts from younger normal and osteoporotic donors show differences in proliferation and TGF- beta release in response to cyclic strain. J Biomech, 1995,28:1411.

二级参考文献7

  • 1申洪.免疫组织化学染色定量方法研究（Ⅲ）[J].中国组织化学与细胞化学杂志,1995,4(1):89-92. 被引量：398
  • 2Wronski TJ,Walsh CC,Ignaszewski LA.Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats[].Bone.1986
  • 3Wozney JM,Rosen V,Celeste AJ,et al.Novel regulation of bone formation: molecular clone and activities[].Science.1988
  • 4Yamaguchi A,Katagiri T,Ikeda T,et al.Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro[].Journal of Cell Biology The.1991
  • 5Maliakal JC,Asahina I,Hauschka PV et al.Osteogenic protein7 ( BMP-7) inhibits cell proliferation stimulates the expression of makers characteristic of osteoblast phenotype in rat osteosarcoma cells[].Growth Factors.1994
  • 6Urist MR,Nillsson OS,Hudak R et al.Immunologic evidence of a bone morphogenetic protein in the milieu interieur[].Annales de Biologie Clinique.1985
  • 7曾敬,丘钜世,徐栋梁,张萌,梁惠珍.成骨细胞培养及冻存复苏后生物学特性比较[J].临床与实验病理学杂志,2000,16(2):137-139. 被引量：7

共引文献33

同被引文献14

  • 1Ambros V.Control of developmental timing in Caenorhabditis elegans.Curr Opin Genet Dev,2000,10:428-433.
  • 2Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function.Cell,2004,116:281-297.
  • 3Ambros V.MicroRN As:tiny regulators with great potential.Cell,2001,107:823-826.
  • 4Healey JH,Zimmerman PA,Mc Donnell JH,et al.Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients.Clin Orthop Relat Res,1990,(256):280-285.
  • 5Babhulkar S,Pande K,Babhulkar S.Nonunion of diaphysis of long bones.Clin Orthop,2005,(431):50-56.
  • 6Moss EG,Poethig RS.MicroRNAs:something new under the sun.Curt Biol,2002.12:R688-690.
  • 7Mattick JS,Makunin IV:Non-coding RNA.Hum Mol Genct,2006,15:R17-R29.
  • 8Brennecke J,Hipfner DR,StarkA,et al.Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapptotic gene hid in Drosophila.Cell,2003,113:25-36.
  • 9Ambros V.MicroRNA pathways in flies and worms:growth,death,fat,stress,and timing.Cell,2003,113:673-676.
  • 10Dostie J,Mourelatos Z,Yang M,et al.Numerous microRNPs in neuronal cells containing novel microRNAs.RNA,2003,9:180-186.

引证文献1

二级引证文献2

中国骨肿瘤骨病
2003年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部