曲美布汀治疗功能性消化不良

Trimebutine in treatment of functional dyspepsia

目的 :比较曲美布汀与西沙必利、甲氧氯普胺治疗功能性消化不良的疗效及安全性。方法 :将2 80例功能性消化不良病人随机分为 3组 ,曲美布汀组 1 0 0例 [男性 3 9例 ,女性 61例 ,年龄 (4 1±s 1 4)a]给曲美布汀 2 0 0mg,po,tid;西沙必利组 90例 [男性 3 1例 ,女性 5 9例 ,年龄 (4 2± 1 3 )a]给西沙必利 1 0mg,po,tid ;甲氧氯普胺组 90例 [男性 3 0例 ,女性 60例 ,年龄 (4 3± 1 1 )a]给甲氧氯普氨1 0mg,po,tid。疗程均为2wk。结果 :总有效率曲美布汀组 85 % ,西沙必利组为 84% ,甲氧氯普胺组为 62 % ,经Ridit分析 ,曲美布汀、西沙必利 2组疗效差异无显著意义 (P >0 .0 5 ) ,曲美布汀、甲氧氯普胺 2组疗效差异有非常显著意义 (P <0 .0 1 )。不良反应曲美布汀、西沙必利 2组相近 ,曲美布汀组明显少于甲氧氯普胺组 (P <0 .0 5 )。结论 :曲美布汀治疗功能性消化不良近期疗效显著、安全 ,与西沙必利相近 。

AIM: To compare the effect and safety of trimebutine, cisapride, and metoclopramide in the treatment of functional dyspepsia (FD). METHODS: Two hundred and eighty patients with functional dyspepsia were randomly divided into three groups. Trimebutine group, one hundred patients M39,F61;age (41± s 14) a were treated with trimebutine, 200 mg, po ,tid for 2 wk. Cisapride group, ninety patients M31,F59;age (42±13) a were treated with cisapride, 10 mg, po , tid for 2 wk. Metoclopramide group, ninety patients M30, F60; age (43±11) a were treated with metoclopramide, 10mg, po , tid for 2 wk. RESULTS:The total effective rates of trimebutine group, cisapride group, and metoclopramide group were 85%, 84%, and 62%, respectively. There were no differences between trimebutine group and cisapride group ( P > 0.05 ). There were obvious differences between trimebutine group and metoclopramide group ( P < 0.01 ). Adverse reactions of trimebutine group were similar to those of cisapride group, less than those of metoclopramide group ( P < 0.05 ). CONCLUSION:Trimebutine is safe and effective in treating FD and similar to cisapride, superior to metoclopramide.