新生儿缺氧缺血性脑病的早期预测

The early prognostication in neonates with the hypoxic-ischemic encephalopathy

目的 :探讨早期预测新生儿缺氧缺血性脑病(HIE)危险性的实验室指标。方法 :对128例窒息新生儿及正常新生儿30例对比研究 ,测定尿乳酸/肌酐(L/C)比值。结果 :128例窒息患儿中 ,78例发生HIE ,发生率为60 94 % ,L/C值≥0.11;其中轻度HIE35例 ,L/C值为0.18±0.07 ;中度HIE25例 ,L/C值为0.29±0.09 ;重度HIE13例 ,其L/C值为0.42±0.07。结论 :尿乳酸盐与肌酐比值可以早期预测HIE的发生 。

Objective:To study the laboratory index of risk for early prognostication of the hypoxic_ischemic encephalopathy(HIE) in neonates. Methods:The ratio of urinary lacatate and creatinine(L/C) was measured in 128 neonates with asphyxia and 30 healthy neonates. Results:78 cases with HIE were discovered in 128 neonates with asphyxia,and the L/C was equal to 0.11 or over.when the L/C was 0.18±0.07,0.29±0.09 and 0.42±0.07,the cases with lightly,middle and heavy HIE were 35, 25 and 13 respectivly.Conclusion:The ratio of L/C may be used for early prognostication of the occurrence of HIE,which can reflect the serious degree of HIE.