真菌及其毒素诱发肺癌的动物实验研究

Experimental lung carcinoma induced by fungi and mycotoxins--A review

目前 ,国内外关于肺癌病因的研究多侧重于空气污染、吸烟、辐射等方面。我们实验室过去几十年的研究中发现 ,饮食中的真菌及其毒素可能在肺癌的发生过程中发挥重要作用 ,从而进行了一系列的研究工作。早期研究结果表明 ,河北省太行山区居民食用的酸菜和接种黄曲霉菌和杂色曲霉菌的玉米面 (其中可检出AFG1和ST)可诱发昆明、LACA和NIH小鼠及Wistar大鼠肺癌。近期研究进一步证实 。

Up to now, most of the etiological studies of lung cancer have been focused on air pollution, radiation and smoking, etc, whereas in the past decades, we had found that fungi and mycotoxins in foodstuff might play important roles in the carcinogenesis of lung cancer. Our preliminary work showed that the liquid in pickled vegetables consumed by residents of Taihang Mountain area in Hebei Province and corn flours inoculated with Aspergillus flavus, Aspergillus versicolor in which aflatoxin G 1 (AFG 1) and Sterigmatocystin (ST) were detected, could induce lung adenocarcinoma in Kunming, LACA and NIH mice as well as Wistar rats. Further studies with AFG 1 and ST confirmed that oral administration of the two mycotoxins could induce lung adenocarconma in NIH mice. The experimental lung carcinoma induction studies with fungi and mycotoxins in our lab are summarized in this review.