抗抑郁剂对小鼠探究行为、自主活动性以及隔离攻击行为的影响(英文)

Effects of antidepressants on the exploration, spontaneous motor activity and isolation-induced aggressiveness in mice

目的 :研究各类抗抑郁剂对小鼠探究行为 ,自主活动性以及隔离攻击行为的药理作用 ,进一步探讨它们抗攻击行为不同的药理学机制。方法 :采用隔离小鼠攻击行为的模型 ,评价各类抗抑郁剂对隔离攻击行为的作用。测定各类抗抑郁剂对群居小鼠探究行为和自主活动性的影响。结果 :(1)米安色林 (0 .5～ 5mg·kg-1) ,丁螺环酮(2 .5～ 10mg·kg-1)和吗氯贝胺 (2 .5～ 10mg·kg-1) ,显著性抑制群居小鼠的探究行为 ,但是 ,氟西汀 (2 .5～ 10mg·kg-1)、丙米嗪 (2 .5～ 10mg·kg-1)和DOI (0 .5～ 2mg·kg-1)对其无明显影响 ;(2 )米安色林和丁螺环酮明显减少群居小鼠的自主活动性 ,而氟西汀、丙米嗪、吗氯贝胺以及DOI无此作用 ;(3)氟西汀 ,米安色林 ,丙米嗪和丁螺环酮剂量依赖性拮抗隔离小鼠的攻击行为 ,吗氯贝胺对此无明显影响。DOI双向调节隔离小鼠的攻击行为。结论 :本实验结果提示 ,氟西汀、米安色林、丁螺环酮、丙米嗪以及DOI对小鼠的探究行为、自主活动性和隔离攻击行为的药理作用并不完全相同 ,可能与它们不同的药理学机制有关。5 HT1A和 5 HT2A/ 2C受体可能介导隔离小鼠的攻击行为 ,有关 5 HT受体亚型介导攻击行为需作进一步研究。

Objective: To study the role of different antidepressants on exploration, spontaneous motor activity and isolation induced aggressiveness in mice, further to discuss different mechanisms of their anti aggression. Methods: With an aggressive model induced by isolation housing in mice, antagonism of different antidepressants against isolation induced aggression was evaluated. In the group housed mice given the same treatment as aggressive test, exploration and spontaneous motor activity were measured. Results: (1) Mianserin (0.5-5 mg·kg -1 ), buspirone (2.5-10 mg·kg -1 ) and meclobemide (2.5-10 mg·kg -1 ) significantly inhibited the exploration in the group housed mice, but not fluoxetine (2.5-10 mg·kg -1 ), imipramine (2.5-10 mg·kg -1 ) and DOI (0.5-2 mg·kg -1 ); (2) Both mianserin and buspirone, but not fluoxetine, imipramine, meclobemide and DOI, obviously reduced spontaneous motor activity; (3) Fluoxetine, mianserin, imipramine and buspirone significantly and dose dependently antagonized isolation induced aggressive behavior, whereas meclobemide failed to attenuate aggression. DOI dual regulated aggressiveness in isolation mice. Conclusion: Our findings suggest that the effects of fluoxetine, mianserin, buspirone, imipramine, meclobemide and DOI on exploration, spontaneous motor activity and isolation induced aggression in mice are different, which may involve different pharmacological mechanisms underlying their anti aggression in isolation mice. 5 HT 1A and 5 HT 2A/2C receptors may mediate isolation induced aggressive behavior in mice. The involvement of 5 HT receptor subtypes needs further clarification.