米非司酮对妊娠早期人绒毛Hofbauer细胞超微结构的影响

Effects of mifepristone on ultrastructure of placental Hofbauer cells in early human pregnancy

目的 探讨米非司酮对妊娠早期人绒毛间质中Hofbauer细胞超微结构的影响。方法 取孕 6～ 9周人工流产者 (对照组 )及米非司酮药物流产者 (观察组 )的绒毛组织各 10例 ,用透视电子显微镜观察其超微结构变化。结果 观察组Hofbauer细胞显著肿胀 ,胞浆突起明显减少 ,偶见胞膜缺损 ,胞浆中的空泡变大 ,含有絮状电子致密物的空泡减少 ;粗面内质网及高尔基复合体欠发达 ;线粒体缩小 ,溶酶体减少 ;胞核增大且出现异常形态 ,染色质浓缩。结论 米非司酮通过影响Hofbauer细胞超微结构 ,使其吞噬能力、水及电解质转运和局部免疫功能改变 。

Objective To investigate the effects of mifepristone on the ultrastructure of Hofbauer cells in human early pregnant placenta. Methods Twenty 6-9 week pregnant women with indications of pregnancy termination were recruited and randomlied to mifepristone (n=10) and D & C group (n=10).Villi were collected and studied with transmission electron microscope. Results In comparison with the control group,the ultrastructure of Hofbauer cells of mifepristone group showed the following changes: the cells were markedly edematous. The number of cytoplasmic processes of Hofbauer cells deceased obviously. In the cytoplasm of Hofbauer cells,the size of vacuoles enlarged and of mitochondrias minimized.Rough endoplasmic reticulum and Golgi complex were under-developed.Lysosomes were rare.The nuclei enlarged and showed irregular shape. Conclusions Mifepristone may change the phagocytosis'water and electrolyte transportation and immunological function of Hofbauer cells by influencing the ultrastructure of the Hofbauer cells.Therefore it can influence the development of pregnancy.