D-二聚体测定与急性早幼粒细胞白血病

Detection of D-dimer and Acute Promyelocytic Leukemia

目的探讨D -二聚体含量与急性早幼粒细胞白血病(APL)经全反式维甲酸(ATRA)治疗前后弥漫性血管内凝血(DIC)发生率的关系及意义。方法应用ELISA法检测21例APL患者(包括7例合并DIC患者)发病时及应用ATRA治疗后D -二聚体水平的变化 ,并与正常对照组比较。结果21例APL患者治疗前血浆D -二聚体水平(2.38±0.98)mg/L较正常对照组(0.25±0.09)mg/L明显升高(P<0.01) ,其中7/21例并发DIC者(2.52±0.12)mg/L明显高于14/21例不并发DIC者 ,(2.18±0.96)mg/L。结论APL患者D -二聚体检测值随维甲酸治疗逐渐降低 。

Objective To study the role of D_dimer(D_D)in disseminated intravascular coagulation(DIC)caused by acute promyelocytic(APL)during all_trans ratinole acid(ATRA)treatment.Methods The plasma level of D_D was measured in21patients with APL(including7cases with DIC)by ELISA,Then compared with normal control group.Results The level of D_D in21patients before treatment(2.38±0.98/mg/L)was sigˉnificantly higher than that in normal control group(0.25±0.09mg/L,P<0.01),7cases with DIC(2.52±0.12mg/L)were snificantly higher than14/21with non_DIC(2.18±0.96mg/L).Conclusions The level of D_D in APL paˉtients was gradually lower during ATRA treatment,It is helpful for judging the clinical status and prognosis.