抗精神病药物治疗精神分裂症的甲状腺功能改变与疗效的相关性分析

An analysis between the changes of thyroidea function and the correlative with efficacy in the antipsychotic drugs treatment of patients with schizophrenia

目的 探索抗精神病药治疗之初的甲状腺功能改变与治疗 4周末疗效的相关性。方法 给 2 3例精神分裂症病人服维思通 (3 6± 0 8)mg/d ,16例精神分裂症病人服氯氮平 (32 8± 6 1)mg/d。在服药治疗的第 4周晨检测T3 、T4和TSH ;服用药 0天和 4周末各测评一次BPRS。结果 ①在氯氮平组 ,T4与 4周末焦虑因子分改善呈正相关性 (r =0 7117,P <0 0 1)。②在维思通组 ,T4水平与 4周末缺乏活力因子分改善呈正相关性 (r =0 4 15 4 ,P <0 0 5 )。结论 ①氯氮平基础剂量 (10 0mg/d)时的T4升高可能预示用氯氮平治疗量到 4周时焦虑症状明显改善。②维思通基础剂量 (1mg/d)时的T4升高可能预示用维思通治疗量到

Objective To explore an correlation between thyroidea function in 4th day of posttreatment and response in 28th day of posttreatment.Methods It was estimated for T 3,T 4 and TSH in 23 schizophrenics takins risperidone 1 mg/d and 16 schizophrenics taking clozapine 100 mg/d when treated for 4th day.It was estimated for brief psychiatric rating scale(BPRS) in 23 schizophrenics taking risperidone(3.6±0.8) mg/d and 16 schizophrenics taking clozapine (328±61)mg/d when treated for 0 day and 28th day,respectively.Results ① There was a positive correlation between T 4 in posttreated 4th day and anxiety improvement in posttreated 28th day in 16 schizophrenics taking clozapine( r =0.7117, P <0.01).②There was a positive correlation between T 4 in posttreated 4th day and anergy improvement in posttreated 28th day in 23 schizophrenics taking risperidone.Conclusion ①T 4 increase in 16 schizophrenics taking clozapine 100 mg/d for 4th day could predict anxiety symptom predominant improvement in these patients taking clozapine (328±61)mg/d for end of 4th week.②T 4 increase in 23 schizophrenics taking risperidone 1mg/d for 4th day could predict anergy predominant improvement in these patients taking risperidone (3.6±0.8)mg/d for end of 4th week.