期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

利用转基因植物作为疫苗生产系统的研究进展 被引量：2

Progress in the use of transgenic plants as vaccine production systems
下载PDF
导出
摘要 植物转化技术是利用分子生物学和基因工程技术 ,将外源基因插入到受体植物的基因组中并使其在后代植株中得以表达的过程。本文就转基因植物作为疫苗生产系统的方法、优点、研究应用等进行综述。
作者 茅海燕
机构地区 浙江大学医学院病原生物学教研室
出处 《浙江大学学报（医学版）》 CAS CSCD 2003年第1期77-80,共4页 Journal of Zhejiang University(Medical Sciences)
关键词 生产系统 研究进展 转基因植物 基因工程疫苗
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献18

  • 1[1]Giddings G, Allison G, Brooks D, et al. Transgenic plants as factories for biopharmaceuticals [J]. Nat Biotechnol,2000,18(11):1151-1155.
  • 2[2]Ma J K. Genes,greens and vaccines [J]. Nat Biotechnol,2000,18(11):1141-1142.
  • 3[3]Arntzen C J. High-tech herbal medicine: plant-based vaccines [J]. Nat Biotechnol,1997,15(3):221-222.
  • 4[4]Richter L J, Thanavala Y, Arntzen C J, et al. Production of hepatitis B surface antigen in transgenic plants for oral immunization [J]. Nat Biotechnol, 2000,18(11):1167-1171.
  • 5[5]Arakawa T, Chong D K, Langridge W H. Efficacy of a food plant-based oral cholera toxin B subunit vaccine [J]. Nat Biotechnol, 1998,16(3):292-297.
  • 6[6]Huang Z,Dry I, Webster D,et al. Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice [J].Vaccine,2001,19(15-16):2163-2171.
  • 7[7]Moffat A S. Exploring transgenic plants as a new vaccine source [J]. Science, 1995,268(5):658-660.
  • 8[8]Nemchinov L G,Liang T J, Rifaat M M, et al. Deve-lopment of a plant-derived subunit vaccine candidate against hepatitis C virus [J]. Arch Virol,2000,145(12):2557-2573.
  • 9[9]Mason H S,Man-Kit Lam D,Arntzen C J. Expression of hepatitis B surface antigen in transgenic plants [J]. Proc Natl Acad Sci U S A,1992,89(24):11745-11749.
  • 10[10]Haq T A, Mason H S, Clements J D, et al. Oral immunization with a recombinant bacterial antigen produced in transgenic plants [J]. Science,1995,268(5):714-716.

同被引文献27

  • 1傅玲琳,帅江冰,Jha Rajeev Kumar,许梓荣.转基因植物疫苗研究进展[J].中国兽药杂志,2005,39(5):22-26. 被引量：2
  • 2冷虹,李加纳,陆合,柴友荣,殷家明.△~6-脂肪酸脱饱和酶基因种子特异表达载体的构建[J].中国农学通报,2006,22(4):66-70. 被引量：1
  • 3SCHIJNSV E,WEINING K C,NUIJTEN P,et al. Immunoadjuvant activities of E. coli and plasmid expressed recombinant chicken 1FN-alpha/beta, 1FN-garmma and IL-1 beta in 1-day-and 3-week-old chickens [J]. Vaccine,2000, 18:2147-2154.
  • 4DIGBY M R, LOWENTHAL J W. Cloning and expression of the chicken interferon-gamma gene[J]. Interferon Cytokine Res, 1995,15:939-945.
  • 5LAMBRECHT B, GONZE M, MORALES D, et al. Comparison of biological activities of natural and recombinant chicken interferon-gamma [ J ]. Veterinary Immunology and Immunopathology, 1999,70: 257-267.
  • 6SONG K D,LILLEHOJ H S,CHOI K D,et al. Expression and functional characterization of recombinant chicken interferon-gamma [ J ]. Vet Immunol Immunopathol, 1997,58 : 321-333.
  • 7WADA K, WADA Y, ISHIBASHI, et al. Codon usage tabulated from the GenBank genetic sequence data[ J]. Nucleic Acids Research, 1992,20 : 2111-2118.
  • 8EDELBAUM O, ILAN N, GRAFI G, et al. Purification and characterization of two antivirally active proteins from tobacco by monoclonal antibodies tohuman beta interferon[ J]. Proc Natl Acad Sci, 1990,87 : 588- 592.
  • 9REINER H, MONIQUE B,ROBERTE B,et al. Transient gene expression in sunflower (Helianthus annuuaL.) following microprojectile bombardment [ J ]. Plant Science, 1995,105 : 95-109.
  • 10VALENTINE N, GALINA E, HYUNG-il L, et al. Highly efficient transient expression of functional recombinant antibodies in lettuce [ J]. Plant Science, 2005,169:433-438.

引证文献2

二级引证文献9

浙江大学学报（医学版）
2003年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部