增龄对心肌细胞流变力学特性的影响

Effect of Aging on Rheological Mechanic Properties of Myocardial Cells

目的 :在已建立的心肌细胞力学模型基础上 ,进一步了解增龄对心肌细胞流变力学特性的影响。方法 :采用微管吸吮技术观察培养的乳鼠、成年鼠心肌细胞的粘弹力学特性。结果 :成年鼠心肌细胞的三个粘弹性系数K1 、K2 和 μ均大于对应的乳鼠心肌细胞的值 ( 6 2 6 .5± 2 2 5.3vs 4 0 7.9± 137.9,32 1.4± 191.0vs 2 2 9.3± 139.6 ,81.3±6 3.1vs 50 .0± 14 .5) ,且二组间差异显著 (P <0 .0 5～ 0 .0 1)。结论 :成年鼠心肌细胞较乳鼠心肌细胞更不易发生变形 ,随着年龄的增长 ,心肌细胞刚性增强 。

On basis of myocardial cell mechanic model,Our aim is to further understand the effect of aging on rheological mechanic properties of the myocardial cells.Method: The viscoelastic properties of the myocardial cells were determined by micropipette aspiration.Results: Compared with the neonatal myocardial cells,The elastic and viscous coefficient of the adult myocardial cells was increased significant ly(626.5±225.3 vs 407.9±137.9,321.4±191.0 vs 229.3±139.6,81.3±63.1 vs 50.0 ±14.5. P<0.05～[FQ(+10mm?160mm,X,BP,DY-W][BHDWG1*4,WK160mm,WK5mmW][XXZSY*5/8-YSY*5/8][BH,WK160mmW]CHINESE JOURNAL OF MICROCIRCULATION·Vol 13,No 1[BHDWG10mm,WK50mm,WK115mmYQ3*4/5W]PAGE· 2 ABSTRACTS OF ORIGINAL ARTICLES 0.01 ).Conclusion: Compared with the neonatal myocardial cells,The adul t myocardial cells couldn′t be deformable.Following age,the stiffness of myocar dial cells increases,and its deformality decreases.