212例糖尿病患者慢性大血管与微血管并发症5年随访

Tracing for Chronic Macrovascular and Microvascular Complications in Patients wi th Diabetes After Five Years

目的 :本文对北京地区 2 12例糖尿病患者进行 5年随访 ,以了解其糖尿病慢性并发症 ,包括大血管及微血管病变情况。方法 :分别对体重指数 (BMI)、血压、心电图、眼底、血脂、尿白蛋白排泄率(UAER)等进行分组检查。结果 :2 12例糖尿病患者中冠心病患病率由 1995年 8.0 %升高至 2 0 0 0年 14 .2 % (P >0 .0 5) ;脑卒中患病率由1995年 7.5%升高至 2 0 0 0年 8.5% (P >0 .0 5) ;糖尿病肾病由 1995年 2 9.2 %升高至 2 0 0 0年 4 7.2 % (P <0 .0 1) ;糖尿病视网膜患病率由 1995年 9.0 %升高至 2 0 0 0年 2 4 .5% (P <0 .0 1)。 2 12例糖尿病患者按血压 <14 0 /90mmHg和血压≥ 14 0 /90mmHg分组随访 ,发现其脑卒中、糖尿病肾病患病率二组间有显著性差异 (P <0 .0 5～ 0 .0 1)。结论 :糖尿病视网膜病变和糖尿病肾病的发生随病程延长明显增多 ,糖尿病时大血管并发症亦随病程延长有增加趋势。对此应早期进行干预治疗 。

To investigate the prevalence of diabetic chronic com plications including macrovascular and microvascular complications of 212 type 2 diabetic patients in Beijing in 1995 and in 2000.Method: Body mass index?blood pressure?ECG?retinal examinatio n were carried out in these patients together with the determination of plasma l ipid and urine albumin excretion.Results: The prevalence of coronary heart disease and stroke in 2000 in diabetic patients were 14.2% and 8.5% respectively,higher than those in 1995(8.0%?7.5%),but there was no statistical significance.The prevalence of dia betic retinopathy in 2000 increased from 29.2% to 47.2%( P<0.01 ).The prevalen ce of diabetic nephropathy in 2000 was 24.5%,significantly higher than that in 1 995(9.0%).The prevalence of diabetic nephropathy and stroke in people with blood pressure≥140/90 mmHg was significantly higher than those with blood pressure<1 40/90 mmHg,( P<0.05 ).Conclusion: Diabetic nephropathy and retinopathy increase with d uration.Early measure of prevention and treatment should be taken,such as anti hypertensive treatment.Diabetic macrovascular complications also increased with duration.