头孢吡肟治疗围术期医院获得性肺炎

Clinical Study of Cefepime's Treatment to the HospitalPerioperative Period Acquired Pneumonia

目的 观察头孢吡肟治疗骨科围术期医院获得性肺炎的疗效及安全性 ,并与头孢他啶进行比较。方法 骨科围术期医院获得性肺炎 70例随机分为两组 :头孢吡肟组 3 5例 ,静滴 1.0～ 2 .0g ,2次 /d ;头孢他啶组 3 5例 ,静滴 1.0～ 2 .0g ,2次 /d ;两组均治疗 1～ 2周。结果 头孢吡肟组及头孢他啶组临床有效率分别为 94.2 9%及 91.43 % (P >0 .0 5 ) ,细菌清除率分别为 94.12 %及 90 .91% (P >0 .0 5 ) ,不良反应发生率均为 2 .86% (P >0 .0 5 )。

Objective To evaluate the effectiveness and safety of Cefepime's treatment to the orthopedic hospital perioperative period acquired pneumonia.Methods 70 cases of patients suffered from this disease were randomly divided into two groups.Half of them were involved in the Cefepime group in which they accepted Cefepime intravenous injection at the dose of 1.0-2.0g,Bid;Another half was named Ceftazidime group and was treated with Ceftazidime at the dose of 1.0-2.0g,Bid.Both of the two groups's treatment period were 1-2 weeks.Results The clinical effective rate to the Cefepime group was 94.29%,to the Ceftazidime group was 91.43%(P>0.05).The bacterial clearance rate to the Cefepime group was 94.12%,to the Ceftazidime was 90.91%(P>0.05).The incidence rate of adverse reaction in both groups were 2.86%(P>0.05).Conclusion Cefepime is effective and safe in the treatment of orthopedic hospital perioperative period acquired pneumonia.