单纯收缩期高血压患者血清一氧化氮水平变化及相关性研究

The change and correlation of NO level in peripheral blood of patients with simple systole hypertension

目的 探讨单纯收缩期高血压患者外周血液一氧化氮 (NO)的浓度变化及其意义。方法 测定 78例原发性单纯收缩期高血压患者空腹外周血液NO浓度 ,并与同期 16例健康体检者相对照。结果 高血压患者的NO浓度是 (4 6.4± 7.8) μg ml。其中 1级高血压为 (5 6.2± 7.8) μg ml,2级高血压为(4 8.5± 11.4) μg ml,3级高血压为 (3 4.7± 13 .2 ) μg ml ;对照组为 (5 7.7± 8.7) μg ml。 结论 单纯收缩压升高也是引起血管内皮功能障碍的一个因素 ,且血压值越高 ,NO水平越低 。

Objective To investigate the change and correlation of nitric oxide (NO) level in peripharal blood of simple systole hypertension patients.Methods NO level was measured in peripheral blood in 78 patients with simple systole hypertension and 16 healthy subjects as control group.Results The concentration of NO in hypertension patient was (46.4±7.8)μg/ml and (56.2±7.8)μg/ml in class Ⅰ,(48.5±11.4)μg/ml in class Ⅱ,(34.7±13.2)μg/ml in class Ⅲ respectively and (57.7±8.7)μg/ml in control group.Conclusion Simple systole hypertension is a factor which may cause the disfunction of vascular endothelial,the higher blood stress is,the more serere damage of vascular endothelial function will be.