四君子汤改善抗生素脱污染小鼠肠道菌群失调的研究

STUDY REGULATION OF CHINESE DRUGS SI JUNZI TANG TO ALTERATION OF INTESTINAL FLORA MOUSE

目的:研究中药四君子汤对肠道菌群失调小鼠的调节作用。方法:小鼠经盐酸林可霉素灌肠造成菌群失调模型。将小鼠分自然恢复组,丽珠肠乐组,四君子汤组。治疗后,进行组织病理学和肠道菌群检测。结果:四君子汤组中肠道菌群量大幅度增加,与自然恢复组相比差异显著,肠道粘膜损伤修复比自然恢复组好。结论:四君子汤能够促进肠粘膜损伤修复,调节肠道菌群失调,是一种理想的微生态调节荆。

Objective:Study regulation of Chinese drugs Si Junzi Tang to alteration of intestinal flora mouse. Methods: Using lincomycin hydrochloride perfuse into gastrointestinal tract to make mouse flora imbalance model. The mouse were divided into three groups: natural recovery group , Liz-huchangle group and Si Junzi Tang group. Histopathology examination and intestinal flora detection were taken after therapy. Results: Intestinal flora quantity increased significantly in Si Junzi Tang group as compared with that in natural recovery group . The intestinal mucosa injury recovery in Si Junzi Tang group is better than that in natural recovery group . Conclusion: Si Junzi Tang can promote intestinal mucosa injury recovery, regulate intestinal flora imbalance. It is a perfect microecosys-tem regulation.