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腹膜透析透出液中表皮生长因子的表达及意义

Epidermal Growth Factor Levels in Peritoneal Dialysis Effluent
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摘要 目的 :研究腹膜透析患者透出液中表皮生长因子 (EGF)的表达情况并探讨其意义。方法 :检测 16例腹透患者血清及腹透液中的 β2 微球蛋白、转铁蛋白及IgG的浓度并进行线性回归分析 ,根据血清含量得出透出液中的EGF预测值 ,与实测值比较。结果 :腹透透出液中EGF表达与预期值相比无差异 ,说明透出液中EGF均为循环转运至腹腔的结果。结论 :腹透时腹腔内缺乏局部自分泌及旁分泌机制 。 Objective:To investigate Epidermal growth factor levels in peritoneal dialysis effluent.Methods:The concentration of β 2-microglobulin?transferrin?albumin and IgGin serum and dialysis were analyzed by linear regression. Then the predicted concentration of EGF in dialysis was obtained and it was compared with the tested concentration. Results:The tested concentration of EGF were not significantly different with predicted when EGF would have been transported from the circulation only by diffusion.Conclusion:There is no evidence for the local production of EGF in the peritoneal memberane of petients undergoing long-term peritoneal dialysis.This suggests a pathogenetic role in HPMCs wound healing.
作者 刘军 徐晓寅 姚建 徐琴君
机构地区 上海市第一人民医院肾内科 上海市第一人民医院中心实验室
出处 《中国中西医结合肾病杂志》 2003年第2期74-76,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
关键词 腹膜透析 表皮生长因子 损伤修复 表达 Peritoneal dialysis Epidermal growth factor Wound healing
分类号 R459.5 [医药卫生—治疗学]
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参考文献11

  • 1[1]Nagy JA, Jackman RW. Anatomy and physiology of the peritoneal membrane. Semin Dial, 1998,11: 49 - 56.
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二级参考文献15

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中国中西医结合肾病杂志
2003年 第2期

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