真胰岛素与免疫活性胰岛素比值在不同血糖水平者测定结果分析

An analysis of rates of true insulin levels to immunoreactive insulin levels in different glucemia subjects

目的 :探讨不同血糖水平者胰岛 β细胞分泌激素中真胰岛所占的比率 ,为临床治疗糖尿病提供指导。方法 :测定糖耐量正常 (NGT)、糖耐量低减 (IGT)和 2型糖尿病 (2TDM)者空腹及餐后 2小时免疫活性胰岛素及真胰岛素浓度并计算比值 ,分析该比值与 β细胞功能的关系。结果 :真胰岛素与免疫活性胰岛素的比值大小依次为 :NGT组 >IGT组 >2TDM组 (P <0 0 1) ;真胰岛素与免疫活性胰岛素比值变化与 β细胞功能变化相似。结论 :免疫活性胰岛素不能客观反映胰岛 β细胞分泌功能 ,所谓的“高胰岛素血症”

Objective:To study the rates of true insulin(I) levels to immune reative insulin levels in different glucemia subjects,and to offer guidance in treatment and research of diabetes.Methods:I and Immunoreactve insulin(IRI) concentrations were measured in normal glucose tolerance(NGT)?impared glucose tolerance(IGT) and 2 type diabetes(2TDM),and rates of I/IRI were counted,and the relation of the rates in NGT?IGT and 2TDM with islet β cell function were analysed.Results:The rates of I/IRI were descreased from groups NGT→IGT→2TDM(P<0 01);The changes of I/IRI rates were similar to the changes of islet β cell function in the three groups Conclusions:In measurement of IRI,the effect of proiusulin should be ignored What was said hyperinsulinemia maybe hyperproinsulin