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乳腺癌中nm23-H1蛋白表达及其意义

Expression of nm23-H1 protein in breast carcinoma and its significance
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摘要 目的 :探讨nm2 3 H1蛋白产物在乳腺癌中的表达特点及其意义。方法 :应用免疫组化S P法检测 92例乳腺癌组织中nm2 3 H1蛋白的表达 ,并分析其与临床病理因素、ER和PR的关系。结果 :92例乳腺癌中nm2 3 H1蛋白阳性表达率为5 7 6 1%。nm2 3 H1蛋白表达阳性率随病理分级增高而降低 ,Ⅰ级与Ⅲ级比较差异有显著性 (P <0 0 5 ) ;无淋巴结转移组明显高于有淋巴结转移组 (P <0 0 5 )。结论 :nm2 3 Objective:To study the expression of nm23 H1 and its significance in breast carcinoma.Methods:S P immunohistochemical technique was used to test the expression of nm23 H1 protein and to observe the relationship between the expression of nm23 H1 and the clinico pathological factors,ER and PR in 92 patients of breast carcinoma.Results:The positive expression rate of nm23 H1 protein in 92 patients of breast carcinoma was 57 61%.There were signficant difference of nm23 H1 expression between the pathological grade Ⅰ and Ⅲ(P<0 05) and between patients with and without limph node metastasis(P<0 05).Conclusion:The detection of nm23 H1 protein is useful for predicting malignancy and metastasis in breast carcinoma.
出处 《广西医学》 CAS 2003年第3期330-332,共3页 Guangxi Medical Journal
关键词 乳腺癌 NM23-H1蛋白 表达 免疫组织化学 Breast neoplasma nm23 H1 Immunohistochemistry
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