持续口服负荷量胺碘酮转复永久性心房纤颤疗效观察

Observation on the efficacy of continued oral load amiodarone on cardioversion in perpetual atrial fibrillation

目的 :探讨持续口服负荷量胺碘酮对永久性心房纤颤 (房颤 )转复窦性心律的有效性与安全性。方法 :选择发作时间为 6～ 12个月 ,左房内径 <5 0cm ,心室率≤ 80次 分的永久性房颤 ,持续口服负荷量胺碘酮治疗 4 6例 (治疗组 )与 35例同类房颤口服常规剂量胺碘酮 (对照组 )对比 ,观察房颤复律的有效性及不良反应。结果 :治疗组 2 8例 (6 0 1% )转为窦性心律 ,显著高于对照组 13例 (17 1% ) ,(P <0 0 5 ) ;因不良反应停药者治疗组 6例 (13 0 % ) ,对照组 4例 (11 4 % ) ,无显著性差异 (P >0 0 5 )。结论 :对选择恰当的永久性房颤 ,持续口服负荷量胺碘酮转复率高、安全。

Objective:To study the efficacy and safety of continued oral load amiodarone on cardioversion in perpetual atrial fibrillation(AF).Methods:The patients in the study accorded with belowing conditions:the perpetual AF with the breaking out at 6～12 months,the internal diameter of left atrium<5 0cm and the rates of ventricle≥80times/min.Of them 46 cases was treated with continued oral load amiodarone(treatment group) and compared with 35 cases of same kind AF oral normal measurement amiodarone(control group).The efficacy and the bad reaction on cardioversion in perpetual AF were observed.Results:Twenty eight cases(60 1%) in treatment group turned to sinus rhythm,were markedly higher than thirteen cases(17 1%) in control group(P<0 05);the cases stopping the medicine because of the bad reaction included six cases(13 0%) in treatment group and four cases(11 4%) in control group,there exist no markedly difference(P>0 05) among them.Conclusions:Continued oral load amiodarone has high rates of cardioversion and safety for the perpetual AF with choice suitable.